The fly cancer screen is a Cancer Research UK supported project, which uses the fruit fly, Drosophila melanogaster, to identify conserved genes that enhance or suppress epithelial tumour progression.
Using the genetic amenability of the fly we generated labelled tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis. We generated a database with 33 different phenotypic categories, each describing a specific aspect of tumour behaviour (see below). This allowed us to record a detailed analysis of how each gene knockdown affected tumour behaviour. See our About page for more information on the screen.
This website is designed to make our database as accessible and user-friendly as possible to all researchers. The database is fully searchable, allowing users to search for their favourite gene, or for the top hits in a particular category. All high-resolution images are available to download.
View genes by category
- Apex size
- Apoptotic
- Basal actin rich spot
- Basal bundles
- Basal protrusions
- Blebbing mitotic cells
- Branched protrusions
- Bright protrusions
- Cell body (rounding)
- Cell length
- Clonal shape
- Clonal tissue
- Closure defects
- Cuticle
- Cyst-like clones
- Defective apex
- Dividing cells
- Freckles
- Individual clone size
- Invading cells
- Invading cells with protrusions
- Junction defect
- Long apical/intermediate protrusions
- Malformed
- Multi-layering
- No apex
- No clones
- Not Developed
- Polarised cytoskeleton
- Single cell clones
- Thick protrusions
- Type of Invasion
- Very long protrusions